Second allografts for relapsed hematologic malignancies: feasibility of using a different donor: Allografting

A second allogeneic hematopoietic stem cell transplant (HSCT) for relapsed hematologic malignancies is an option in select patients after an initial allograft has failed. If the original donor is not available, a different donor may have to be considered. We report our experience of performing a sec...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 2005-02, Vol.35 (3), p.261-264
Hauptverfasser: Duus, J E, Stiff, P J, Choi, J, Parthasarathy, M, Rodriguez, T, Toor, A A
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Sprache:eng
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Zusammenfassung:A second allogeneic hematopoietic stem cell transplant (HSCT) for relapsed hematologic malignancies is an option in select patients after an initial allograft has failed. If the original donor is not available, a different donor may have to be considered. We report our experience of performing a second allogeneic HSCT using a different donor in patients with relapsed leukemia and lymphoma. In a 5-year period, six patients underwent a second allograft with myeloablative conditioning using a different donor. Four of these were retransplanted using a matched-unrelated donor. Four of the patients (67%) remain progression-free at a median follow-up of 32 months (range 3–72). There were no cases of transplant-related mortality. We conclude that a second allogeneic HSCT using a different donor is a viable option for selected patients relapsing after an allograft if the original donor is not available.
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1704761