Poor prognosis of NSCLC located in lower lobe is partly mediated by lower frequency of EGFR mutations

It is controversial whether a tumor located in the lower lobe is related with worse outcome of non-small cell lung cancer (NSCLC). This study aimed to clarify the prognostic role of primary tumor location in NSCLC. Patients newly diagnosed with NSCLC in a tertiary referral hospital from January 2011...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.14933-14933, Article 14933
Hauptverfasser:	Lee, Hyun Woo, Park, Young Sik, Park, Sangshin, Lee, Chang-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/409 692/420/2489/68/2486 Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Adenocarcinoma of Lung - surgery Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Breast cancer Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Disease ErbB Receptors - genetics Female Follow-Up Studies Gelatinase B Gene Expression Regulation, Neoplastic Genes Health risks Histology Humanities and Social Sciences Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - surgery Male Metastases Metastasis Middle Aged Mortality risk multidisciplinary Multidisciplinary Sciences Mutation Mutation Rate Prognosis Retrospective Studies Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Sensitivity analysis Survival Rate
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Zusammenfassung:	It is controversial whether a tumor located in the lower lobe is related with worse outcome of non-small cell lung cancer (NSCLC). This study aimed to clarify the prognostic role of primary tumor location in NSCLC. Patients newly diagnosed with NSCLC in a tertiary referral hospital from January 2011 to December 2014 were followed up for 5 years. Of the 2,289 NSCLC cases, 911 (39.8%) cases pertained to lower lobe cancers. Patients with lower lobe cancer showed a higher all-cause mortality rate than those with non-lower lobe cancer (48.6% vs. 40.3%, p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-71996-7