Tipping the balance in CD4+ T cells: Aging immunity
Signaling via T cell antigen receptors is diminished during aging. But paradoxically, CD4 + T cells from older adults tend to differentiate into effector-like rather than memory cells. An altered balance between the activities of HELIOS, IL-2Rα, and STAT5 influences this decision.
Gespeichert in:
| Veröffentlicht in: | Nature immunology 2023, Vol.24 (1), p.8-9 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Signaling via T cell antigen receptors is diminished during aging. But paradoxically, CD4
+
T cells from older adults tend to differentiate into effector-like rather than memory cells. An altered balance between the activities of HELIOS, IL-2Rα, and STAT5 influences this decision. |
|---|---|
| ISSN: | 1529-2908 1529-2916 |
| DOI: | 10.1038/s41590-022-01389-7 |