EZH2 accompanies prostate cancer progression

EZH2 accompanies prostate cancer progression

Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate tran...

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Veröffentlicht in:Nature cell biology 2021-09, Vol.23 (9), p.934-936
1. Verfasser: Xin, Li
Format: Artikel
Sprache:eng
Schlagworte:
631/67/589/466
631/67/68/2486
692/699/67/1059/2326
Analysis
Androgen receptors
Biomedical and Life Sciences
Cancer Research
Castration
Cell Biology
Development and progression
Developmental Biology
Enzymes
Genetic transcription
Homology
Life Sciences
Life Sciences & Biomedicine
News & Views
news-and-views
Prostate cancer
Science & Technology
Stem Cells
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Beschreibung
Zusammenfassung:Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate transition of CRPC into a lineage infidelity state.
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-021-00744-4