HLA-DRB1, IRF5, and CD28 gene polymorphisms in Egyptian patients with rheumatoid arthritis: susceptibility and disease activity

HLA-DRB1, IRF5, and CD28 gene polymorphisms in Egyptian patients with rheumatoid arthritis: susceptibility and disease activity

This study was established to assess the effects of IRF5 rs10488631 and CD28 rs1980422 single-nucleotide polymorphisms (SNPs) and HLA-DRB1 shared epitope (SE) allele on the prognosis and disease activity of rheumatoid arthritis (RA) patients. A total of 150 RA patients and 150 healthy controls were...

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Veröffentlicht in:Genes and immunity 2021-06, Vol.22 (2), p.93-100
Hauptverfasser: Said, Nora M., Ezzeldin, Nillie, Said, Dina, Ebaid, Amany M., Atef, Dina M., Atef, Rehab M.
Format: Artikel
Sprache:eng
Schlagworte:
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Alleles
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
CD28 antigen
CD28 Antigens - genetics
Cellular proteins
Drb1 protein
Egypt
Epitopes
Gene Expression
Gene polymorphism
Genetic aspects
Genetic Predisposition to Disease
Genetic research
Genetics & Heredity
Genotype
Health aspects
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
HLA-DRB1 Chains - genetics
Human Genetics
Humans
Immunology
Interferon Regulatory Factors - genetics
Life Sciences & Biomedicine
Methotrexate
Polymorphism, Single Nucleotide
Prognosis
Rheumatoid arthritis
Rheumatoid factor
Risk factors
Science & Technology
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Tissue typing
Transcription factors
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Zusammenfassung:This study was established to assess the effects of IRF5 rs10488631 and CD28 rs1980422 single-nucleotide polymorphisms (SNPs) and HLA-DRB1 shared epitope (SE) allele on the prognosis and disease activity of rheumatoid arthritis (RA) patients. A total of 150 RA patients and 150 healthy controls were genotyped for the selected SNPs by real-time PCR. HLA-DRB1 SE was determined using LAB Type SSO Class II DRB1 typing. Our results suggest that HLA-DRB1 , CD28 , and IRF5 significantly discriminated ( p  
ISSN:1466-4879
1476-5470
DOI:10.1038/s41435-021-00134-8