Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate

Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2-chloro- N -(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70–80 °C for 7 h to give the grafted polymer, which condensed with cyclohexanone Mannich base 45 °C for 7 h to afford the corresponding (SCN). These were stirred with Deflazacort drug to achieve the Deflazacort loading (SCN), which, compressed with calcium starch glycolate (CaSgly) to give the corresponding tablets. The pH 2. 1 and concentration of SCN-10 %/CaSgly (1:4) was found to be important parameters in controlling the release profiles.