Acute kidney injury and vancomycin/piperacillin/tazobactam in adult patients: a systematic review

The aim of this systematic review was to assess AKI (acute kidney injury) in adult patients, treated with vancomycin ( V ) + piperacillin/tazobactam (PT) compared to V monotherapy. Studies were found in Pubmed, Web of Science and Scopus databases. Articles not in English, pediatric studies and case...

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Veröffentlicht in:	Internal and emergency medicine 2020-03, Vol.15 (2), p.327-331
Hauptverfasser:	Ciarambino, Tiziana, Giannico, Orazio Valerio, Campanile, Amalia, Tirelli, Paolo, Para, Ombretta, Signoriello, Giuseppe, Giordano, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Case reports CE-Systematic reviews and meta-analysis General & Internal Medicine Internal Medicine Kidneys Life Sciences & Biomedicine Medicine Medicine & Public Health Medicine, General & Internal Piperacillin Science & Technology Systematic review Tazobactam Vancomycin
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Beschreibung
Zusammenfassung:	The aim of this systematic review was to assess AKI (acute kidney injury) in adult patients, treated with vancomycin ( V ) + piperacillin/tazobactam (PT) compared to V monotherapy. Studies were found in Pubmed, Web of Science and Scopus databases. Articles not in English, pediatric studies and case reports were excluded. A study is eligible for inclusion if the adjusted Odds ratio (aOR) for AKI in V + PT compared to V monotherapy groups, could be extracted or determined from available data. Six retrospective cohort studies were eligible for inclusion criteria and so they were included in the analysis. All studies separately showed a significant higher risk of developing AKI (OR > 1, p
ISSN:	1828-0447 1970-9366
DOI:	10.1007/s11739-020-02287-2