Two new diterpenoids from Leonotis leonurus R. Br

Two new diterpenoids from Leonotis leonurus R. Br

Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide ( 1 ) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide ( 2 ) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic...

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Veröffentlicht in:Journal of natural medicines 2015, Vol.69 (1), p.130-134
Hauptverfasser: Narukawa, Yuji, Komori, Miyuki, Niimura, Akiko, Noguchi, Hitomi, Kiuchi, Fumiyuki
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Plant Sciences
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Zusammenfassung:Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide ( 1 ) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide ( 2 ) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-014-0868-2