Synthesis and Anticonvulsant Activity of New 2-(4-Oxo-2-Thioxo-1,4-Dihydro-3(2h)-Quinazolinyl)Acetamides

A search for new anticonvulsants led to a series of 2-(4-oxo-2-thioxo-1,4-dihydro-3(2 H )-quinazolinyl)- acetamides that were synthesized by reacting (4-oxo-2-thioxo-1,4-dihydro-3(2 H )-quinazolinyl)acetic acid with the appropriate amines in the presence of N , N ′-carbonyldiimidazole. The tested compounds showed weak and moderate anticonvulsant effects in a pentylenetetrazole-induced seizure model in mice. Several features of the structure—activity relationships are discussed.