MiR-6838-5p facilitates the proliferation and invasion of renal cell carcinoma cells through inhibiting the DMTF1/ARF-p53 axis

Renal cell carcinoma (RCC) is one of the most common renal malignancies in the urinary system. Numerous studies have demonstrated that miRNAs can regulate tumorigenesis and progression. This study aims to investigate the role and regulatory mechanism of miR-6838-5p in RCC. Our study confirmed that m...

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Veröffentlicht in:	Journal of bioenergetics and biomembranes 2021-04, Vol.53 (2), p.191-202
Hauptverfasser:	Zhai, Xiaoqiang, Wu, Yan, Zhang, Dong, Li, Hecheng, Chong, Tie, Zhao, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Biochemistry Bioinformatics Bioorganic Chemistry Biophysics Biotechnology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Biology Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - physiology Chemistry Chemistry and Materials Science Cholecystokinin Cyclin D Cytoprotection - physiology Epithelial cells Epithelium HEK293 Cells Histology Homology Humans Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Life Sciences & Biomedicine MDM2 protein MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - metabolism Morphology Neoplasm Invasiveness Organic Chemistry p53 Protein Proteins PTEN protein Regulatory mechanisms (biology) Renal cell carcinoma Reporter gene RNA, Messenger - genetics RNA, Messenger - metabolism Science & Technology Signal transduction Tensin Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Protein p14ARF - genetics Tumor Suppressor Protein p14ARF - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis Up-Regulation Western blotting
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Zusammenfassung:	Renal cell carcinoma (RCC) is one of the most common renal malignancies in the urinary system. Numerous studies have demonstrated that miRNAs can regulate tumorigenesis and progression. This study aims to investigate the role and regulatory mechanism of miR-6838-5p in RCC. Our study confirmed that miR-6838-5p was upregulated in human RCC tissues (30/42, 77.43%, P
ISSN:	0145-479X 1573-6881
DOI:	10.1007/s10863-021-09888-2