Pancreatic Differentiation from Murine Embryonic Stem Cells

Pluripotent stem cells are considered as a cell source for replacement therapies for pancreatic beta cells and other organs. We identified tetrabenazine (TBZ), vesicular monoamine transporter 2 (VMAT2) inhibitor as a promoter of late-stage differentiation of Pdx1-positive pancreatic progenitor cells...

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Veröffentlicht in:	Embryonic Stem Cell Protocols 2016-01, Vol.1341, p.417-423
Hauptverfasser:	Sakano, Daisuke, Shiraki, Nobuaki, Kume, Shoen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques - methods Cell Differentiation - drug effects Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects GSIS Homeodomain Proteins - analysis Mice Pancreas - cytology Pancreatic differentiation Tetrabenazine - metabolism Trans-Activators - analysis Vesicular Monoamine Transport Proteins - antagonists & inhibitors VMAT2 inhibitor
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