SU‐FF‐J‐146: Sequential Volume Change Estimation of Breast Tumor From Whole Breast Automated Ultrasound by Reader Study

Purpose: To evaluate use of image based registration in volume change estimation of breast tumor by expert reader study of three‐dimensional (3D) ultrasound (US) whole breast image volumes. Methods: 3D US volumes of tumors in nearly whole breast sweeps using mammography‐style compression were acquired using the Logiq‐9 10L transducer (GE Healthcare, Waukesha, WI). Nearly whole breast scanning was performed before, during and after 115±14 days of chemotherapy on 7 patients. Three breast radiologists marked a 3D ellipsoid around the tumor on pairs of pre‐ chemotherapy with mid‐ or post‐chemotherapy US image volumes, spatially unregistered or registered in a pseudo‐random order. Additional information including pre‐chemotherapy US hand scan(s), mammograms and a clinical findings report without tumor dimensions was provided. Results: Preliminary results on the first 3 of 7 cases showed that registration provided a nearly significant reduction in the statistical uncertainty in reader estimates of normalized fractional tumor volume change due to chemotherapy (p‐value