Comparative analysis of antifungal properties of Moringa derivatives over commercial antibiotics

As an alternative to the antifungal medications that are presently on the market, the major purpose of this investigation is to assess the effectiveness of Moringa derivatives. Utilizing molecular docking methods, the researchers will explore the interactions between ligands, proteins, and antifungal medications on a molecular level. The Instruments and Methods Used in Research: Obtaining the three-dimensional structures of the ligands and proteins required the usage of PubChem, Drugbank, and PDB. Twenty photographs are included in the collection, and they are distributed evenly between two distinct categories. The picture files used in the study are all PNGs with a resolution of 96 dots per inch and a size of 512×512 pixels. In order to estimate the sample size, the G power was utilised, along with a pretest power of eighty percent and an alpha value of 0.05. There are a total of thirty persons, with ten individuals joining each of the groups. Docking studies of ligands and proteins were carried out with the use of software known as auto dock. Statistical analysis of the interactions was carried out with the assistance of the IBM SPSS programme. Compared to myricetin and terbinafine, the results of molecular docking experiments demonstrated that thiram had a stronger affinity for the protein. When the binding affinity values were analysed with SPSS software, it was shown that there was a statistically significant relationship between Myricietin and thiram (p=0.0001) and between Myricietin and terbinafine (p=0.0001). Antifungal medication thiram appears to be more focused and effective against the target protein when compared to myricetin and terbinafine, according to the findings.