Synthetic coral scaffold incorporated platelet rich plasma induce angiogenesis post tooth extraction

Tooth extraction is one of the most performed procedures in dentistry. This action causes alveolar bone damage and changes in soft tissue structure. The synthetic coral scaffold as a component of tissue engineering used in this study is capable of triggering bone tissue regeneration. The scaffolds were incorporated Platelet Rich Plasma (PRP) which contains various growth factors. It can trigger angiogenesis. Angiogenesis has an important role in the regeneration of bone tissue because it influences transportation of minerals, oxygen and nutrients for this process. This study aims to determine the use of synthetic coral scaffolds incorporated PRP for angiogenesis process after tooth extraction on animal study (Rattus norvegicus). The 48 male Rattus Norvegicus, Wistar strain which were then divided into 4 treatment groups, namely the povidone iodine group (negative control), Curaspon@ (positive control), synthetic coral scaffold incorporated PRP, and Scaffold only. The rats were sacrificed, the maxillary section was cut, then histological preparations were made to observe the number of blood vessels. Observations were made on days 7, 14, 21, and 28. The results showed that there were significant differences between treatments on day 28, where synthetic coral scaffold incorporated PRP was significantly different from Povidone Iodine and scaffolds without PRP. This indicates that there is a faster rate of angiogenesis in the synthetic coral scaffold that was incorporated PRP.