Evaluation serum level of IL-17, IL-23 and IL-35 in patients with bacterial prostatitis in Najaf Province

This investigation aims to evaluate the levels of IL-17, IL-23, and IL-35 in prostate inflammation patients and identify bacterial agents to gain further insights into outcome of prostatitis and improve treatment options for this condition. A patient - healthy study was design on 90 prostatitis patients and 30 healthy control subjects. Blood and semen samples were collected from all participant to measure concentration of interlukine-17, 23, and 35 by ELISA assay, identify bacterial agents by culturing on general and differential media and confirmed by Vitek system, also evaluate semen characteristics. The study found that E. coli, K. pneumonia, and S. aureus were the leading causes of prostatitis infection. The IL-17 and IL-23 concentration were highly elevated in both acute and chronic prostatitis patients, with the highest levels observed in patients with chronic prostatitis. A decrease in IL-35 levels was also observed in both acute and chronic prostatitis. The study found IL-17 and IL-23 have a positive association, while IL-17 and IL-35 have a negative correlation.