Gum linum usitatissimum-g-poly (acrylamide): Microwave-assisted synthesis, characterization and release behaviour

Microwave grafting of Linum usitatissimum gum on poly(acrylamide) was performed using a three-level four-factor central composite experimental design. Gum linum usitatissimum-g-poly (acrylamide) was characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. Microwave power, microwave exposure time, and ammonium persulfate concentration had a significant synergistic effect on grafting efficiency, while Linum usitatissimum gum concentration had no significant effect. The optimal calculated parameters were microwave power-80%, microwave exposure time-70s, concentration of ammonium persulfate-0.4g and concentration of gum linum usitatissimum-1g, acrylamide 7.5g. The maximum grafting efficiency was 90.7 percent. Comparative in vitro release evaluation of lornoxicam from gum linum usitatissimum-g-polyacrylamide and gum linum usitatissimum-g-polyacrylamide matrix tablets revealed sustained drug release from gum linum usitatissimum-g-polyacrylamide. It was observed that as the percentage of natural polymer increased, the release rate decreased, although the drug release pattern was mainly dependent on the type of polymer. A dissolution study demonstrated that Linum usitatissimum seed mucilage can be used as a matrix-forming material for the production of Lornoxicam 24-hour sustained-release matrix tablets.