Fish oil supplementation effect on coronary heart disease secondary prevention: A systematic review and meta-analysis

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios. Current finding and evidence of fish oil effect to prevent and treat CHD have shown a large variety of effects and conflicting results with low levels of evidence. This systematic review and meta-analysis collect, summarize, and analyzed those findings and evidence to elaborate more meaningful and stronger evidence to support future clinical application. Search for published sciezntific articles using the PRISMA (Preferred Reporting, Items for Systematic Reviews and Meta-Analysis) method conducted on PubMed Central, Medline, and Cochrane using the following keywords: “EPA-DHA” AND “fish oil supplementation” AND “CHD” AND “secondary prevention”. Further systematic review and meta-analysis using RevMan version 5.4 were performed based on the included published scientific articlesBased on 9 studies included that compared the effect of fish oil supplementation with placebo, the analytical results showed a statistically significant overall effect (P