Kinetics study for the controlled release of salbutamol from a new PVA-based hydrogel matrix

The study includes loading the drug on two types of polymeric gel networks they are the first matrix: made of chitosan with polyvinyl alcohol (PVA), which is characterized by being biocompatible and sensitive toward the acidic function (pH), and they have distinctive properties that are safe to use in broad medical fields. The second matrix comprises polyvinyl alcohol (PVA) and polyethylene glycol (PEG), a highly flexible and water-soluble compound. The matrix has a variety of uses in chemistry and medicine, including the creation of osmotic pressure, making it a chemically significant substance with low toxicity. The component ratios for the first and second matrix polymers were investigated to achieve the best polymeric structure qualities. The best polymeric matrix ratios were the first composed of 15 ml of PVA and 5 ml of chitosan because they provided the best stability and swelling rate (158%) when 4 ml of the cross-linking agent glutaraldehyde was added. The second matrix polymer that performed the best in terms of stability and swelling rate (285 %) when 3ml of a cross-linking agent was introduced was made up of 3ml PVA and 3ml PEG. A study was conducted on the kinetics of the swelling of the polymeric gel reticle according to the zero, first and second order kinetics models. The drug was carried on samples from the first and second matrices. Then the slow release of the drug was studied in two types of virtual fluids, the first is the simulated gastric fluid (SGF), and the second is the simulated intestinal fluid (SIF). Spectrophotometric measurements of salbutamol were made in a SIF solution and SGF solution with a concentration of (2.2 X 10-2 M) so that the compound in the two solutions gave the highest absorption value at the maximum wavelength of (λmx= 225).