Chromone a versatile moiety for bioactive lead molecules

Chromone ring which is extensively found in nature as benzo g pyrone, consists of heteroatom oxygen attached to benzene ring (4H-1-benzopyran-4-one). They are known to exhibit a wide variety of biological activities like antioxidant, antimicrobial, anti-inflammatory, neuroprotection, anti-cancer, anti-diabetic and many more. Many investigations have shown that the antioxidant properties of chromone prevents further damage like Alzheimer’s disease by inhibiting MAOs and many multitargeted drugs are developed in this lead. Moreover, by preventing the release of NO•, it inhibits inflammation from some dreadful disease. Many researches have used these chromone molecules for study of antioxidant properties and to look onto the effects of various substituents on the antioxidant activities. These chromone derivatives have shown a significant enhancement in the activities by forming the metal complex of chromone.