Synthesis and characterization of novel platinum complexes containing ciprofloxacin as anti-cancer drugs

Schiff base complexes have played an important role in the different fields of chemistry for biological, analytical, industrial, and pharmaceutical applications. Over the last few decades, new transition metal complexes of Schiff base ligand metal have gained considerable attention and developed. The synthesis of novel ligands is the significant attempt in the development of the transition metal complexes that show individual properties and new reactivity. The work takes into an account the design, synthesis and characterization of the derivatives of ciprofloxacin coordinated with Pt(II) and Pt(IV) complexes. Attaching Cipro-derivatives to cisplatin led to the release of two separate types of medicines inside cancer cells, which were then subjected to different processes on various targets. As a result, Cipro-derivatives to platinum conjugates might be used to target tumor cells in addition to the free anticancer cisplatin component, as well as free Cipro-derivatives that could allow them to carry out their biological activity. NMR spectroscopy and mass spectrometry were used to characterize the organic ligands and their complexes. The coordination connection was formed between the metal center ion and the synthesized ligands through a nitrogen atom in the platinum complexes, according to spectroscopic analyses. Compounds D1, D2, D3 and D4 were designed and synthesized to release one molecule of Cipro along with the platinum complex containing two chlorides as leaving groups.