Bioactivity compound prediction of Saurauia vulcani as immunostimulant: An in silico approach

Immunostimulatory effect of Pirdot (Saurauia vulcani) has been reported previously. However, molecular interactions tend to be involved in mechanism of immunostimulatory activity has not been clarified. Our previous study indicated that ethanol extract of Pirdot leaves affected significantly the number of erythrocyte and spleen histological structure. Therefore, the purpose of the present study was to elucidate molecular bioactivity interaction of bioactive compound Pirdot with protein induced immunostimulant function through in silico approach. As a result, there were three bioactive compounds of Pirdot to interact with immunotherapeutic agents in protein-protein interaction pathway, such as ursolic acid, stigmasterol, and genistein. Moreover, its bioactive compound bound to active site of IL-8 and IL-6 that ursolic acid has the highest value than stigmasterol and genistein, respectively.