Antidiabetic activity methanol extract of cingkam stem bark (Bischofia javanica)

The purpose of this study was to determine the levels of total phenols and flavonoids and to determine the antidiabetic activity of the methanol extract of the bark of the cingkam plant (B. javanica). The experimental animals were divided into 4 groups with 5 white wistar strain rats in each treatment, namely STZ-induced diabetes control (I), diabetic rats were given methanol extract of cingkam stem bark at a dose of 250 mg/KgBW (II) and 500 mg/kg. KgBW (III) and diabetic rats were given metformin at a dose of 10 mg/KgBW (IV). Test of total phenol and flavonoid using UV-Vis spectrophotometry. The results showed that the total phenol and flavonoid levels of the methanol extract were 118.03 mg GAE/g and 1.64 mg QE/g, respectively. The results of body weight measurement showed a significant difference between 250 mg and 500 mg of the methanol extract on day 14. The body weight of diabetes control and 500 mg of the methanol extract decreased on the 14th day. The methanol extract of cingkam stem bark was able to reduce the fasting blood sugar levels of STZ when compared to diabetic control rats but much lower than metformin.