Tracking the production levels of mannose binding lectin (MBL) and serotonin (SRT) for prediction of childhood acute lymphoblastic leukemia (ALL) in Iraq

During the extended period in between the beginning of March 2019 and the end of February 2020, 71 residents were enrolled in the present work. 31 samples of children patients with ALL, who had no historic family of cancer were collected from the Hematology and Oncology centre of Imam Al-Hussain Hospital in Kerbala, Iraq. (before provided them chemotherapy and followed up to four chemotherapeutic doses). The statistical analysis using the Student's t-test showed significant differences for MBL and SRT when compared the patients with ALL and healthy children together. The results of the study also presented a statistically significant increase, in respectively for MBL and SRT levels in male and female patients with ALL compared with their peers in the control group, whereas no significant differences were observed in MBL and SRT levels when the intra-subgroups compared, separately. The study outcomes recorded a rise in MBL levels in 29 out of the 31 residents’ patients at 94%, and then noted a reduction in the serum levels of MBL at 68% of 21 out of 31 patients with ALL after received the 2nd and 3rd doses of therapy. The MBL levels in patients resumed increasing after the 4th dose of chemotherapy. In addition, SRT levels increased in 13 out of 31 patients with ALL by 42% pre- chemotherapy, and then its concentrations continuous decreased at 71% in 22 out 31 children with ALL after delivered 1st and 2nd doses of chemotherapy, while MBL levels presently re-decreased yet again after the 4th dose of chemotherapy.The evaluation result of correlation relationship between MBL and SRT levels was demonstrated a negative significant correlation (r=-0.523at p