Immunobiological resistance and humoral protection factors in animals

Pathogens of acute intestinal infections, in particular escherichia coli, are relevant among various diseases of newborn piglets, such as escherichioses, streptococcosis, clostridiosis and others. To improve the prevention of these pathologies, comprehensive information on immunobiological resistance and humoral protection factors in animals is needed. In this aspect, the formation of intestinal microbiocenosis in the first days of piglets ’ life, as well as the dynamics of the accumulation and formation of immunoglobulins to significant pathogens and their antigens, are of great importance. Studies conducted on piglets have shown that colonization of the small and large intestine occurs mainly by bacteria of the genera Escherichia, Streptococcus, Clostridium, Bifidumbacterium, Lactococcus, Lactobacterium. With age, with the relative stability of the symbiotic microflora, hemolytic forms of streptococci, escherichia, and staphylococci appear in the intestine. In turn, the body compensates for these changes in the intestinal microflora by the activity of the cellular link of immunity, in particular neutrophils and their phagocytic and digesting ability, as well as by stimulating the humoral link of immunity and antibody formation. Vaccination of sows with drugs based on inactivated exotoxins of escherichia coli provides the offspring with a sufficient amount of antitoxic antibodies in the first three days of life, during which the newborn body is most vulnerable to the disease. At the same time, vaccination with complex biologics with three types of toxoids is more effective.