Synthesis and toxicity test of 2’-hydroxy-5’-chloro-3,4-dymethoxychalcone

This study was aimed to synthesis the chalcone derivative and tested its toxicity. Synthesis of 2’-hydroxy-5’-chloro-3,4-dimethoxychalcone carried out through Claisen-Schmidt condensation at room temperature. The toxicity test prepared by Brine Shrimp Lethality Test (BSLT) to Artemia Salina L. Analy...

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Hauptverfasser:	Mulyani, Melia, Farah, Harra Ismi, Rusli, Rolan, Rahmadani, Agung
Format:	Tagungsbericht
Sprache:	eng
Schlagworte:	Acetophenone Artemia Benzaldehyde Lethality NMR Nuclear magnetic resonance Room temperature Synthesis Toxicity testing
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creator	Mulyani, Melia Farah, Harra Ismi Rusli, Rolan Rahmadani, Agung
description	This study was aimed to synthesis the chalcone derivative and tested its toxicity. Synthesis of 2’-hydroxy-5’-chloro-3,4-dimethoxychalcone carried out through Claisen-Schmidt condensation at room temperature. The toxicity test prepared by Brine Shrimp Lethality Test (BSLT) to Artemia Salina L. Analysis retrosynthetic gives the 2-hydroxy-5-chloro acetophenone and 3,4-dimethoxy benzaldehyde as starting materials. The desire chalcone was confirmed by 1H and 13C NMR, also mass spectroscopy. The chalcone obtained in 83.27% and exhibited LC50 value in 974.99 µg/mL.
doi_str_mv	10.1063/5.0059535
format	Conference Proceeding
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Yahya</au><au>Joris, Shielda Natalis</au><au>Seumahu, Cecilia Anna</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Synthesis and toxicity test of 2’-hydroxy-5’-chloro-3,4-dymethoxychalcone</atitle><btitle>AIP conference proceedings</btitle><date>2021-09-28</date><risdate>2021</risdate><volume>2360</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>This study was aimed to synthesis the chalcone derivative and tested its toxicity. Synthesis of 2’-hydroxy-5’-chloro-3,4-dimethoxychalcone carried out through Claisen-Schmidt condensation at room temperature. The toxicity test prepared by Brine Shrimp Lethality Test (BSLT) to Artemia Salina L. Analysis retrosynthetic gives the 2-hydroxy-5-chloro acetophenone and 3,4-dimethoxy benzaldehyde as starting materials. The desire chalcone was confirmed by 1H and 13C NMR, also mass spectroscopy. 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source	AIP Journals Complete
subjects	Acetophenone Artemia Benzaldehyde Lethality NMR Nuclear magnetic resonance Room temperature Synthesis Toxicity testing
title	Synthesis and toxicity test of 2’-hydroxy-5’-chloro-3,4-dymethoxychalcone
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