Continuous stacking computational approach based automated microscope slide scanner
Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. In this article, a computation augmented approach for the development of an automated microscope slide scanner is presented. The realization of a prototype device built usin...
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| Veröffentlicht in: | Review of scientific instruments 2018-02, Vol.89 (2), p.023701-023701 |
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| container_title | Review of scientific instruments |
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| creator | Murali, Swetha Adhikari, Jayesh Vasudeva Jagannadh, Veerendra Kalyan Gorthi, Sai Siva |
| description | Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. In this article, a computation augmented approach for the development of an automated microscope slide scanner is presented. The realization of a prototype device built using inexpensive off-the-shelf optical components and motors is detailed. The applicability of the developed prototype to clinical diagnostic testing is demonstrated by generating good quality digital images of malaria-infected blood smears. Further, the acquired slide images have been processed to identify and count the number of malaria-infected red blood cells and thereby perform quantitative parasitemia level estimation. The presented prototype would enable cost-effective deployment of slide-based cyto-diagnostic testing in endemic areas. |
| doi_str_mv | 10.1063/1.5022549 |
| format | Article |
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The presented prototype would enable cost-effective deployment of slide-based cyto-diagnostic testing in endemic areas.</description><subject>Automation</subject><subject>Diagnostic systems</subject><subject>Diagnostic tests</subject><subject>Digital imaging</subject><subject>Erythrocytes</subject><subject>Image acquisition</subject><subject>Image quality</subject><subject>Malaria</subject><subject>Optical components</subject><issn>0034-6748</issn><issn>1089-7623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp90MtKxDAUBuAgijOOLnwBKbhRoWNO2uaylMEbDLhQ1-U0SbVj29SmXfj2ZujowoVZJIF8HPL_hJwCXQLlyTUsM8pYlqo9MgcqVSw4S_bJnNIkjblI5Ywceb-hYWUAh2TGVKoySdWcPK9cO1Tt6EYf-QH1R9W-Rdo13TjgULkW6wi7rneo36MCvTURjoNrcAi3ptK989p1NvJ1ZcKusW1tf0wOSqy9PdmdC_J6d_uyeojXT_ePq5t1rJNUDrGEwiojGTCtBILRlBnGhFSAWaKwKAVDUSrIOJSy1FKiSLW22vDwbjhPFuRimhv-9zlaP-RN5bWta2xtyJMzCjQRnEIS6PkfunFjH9IFBZDJALkK6nJS21y-t2Xe9VWD_VcONN82nUO-azrYs93EsWis-ZU_1QZwNQGvq6nLf6Z9A5PShdw</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Murali, Swetha</creator><creator>Adhikari, Jayesh Vasudeva</creator><creator>Jagannadh, Veerendra Kalyan</creator><creator>Gorthi, Sai Siva</creator><general>American Institute of Physics</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Continuous stacking computational approach based automated microscope slide scanner</title><author>Murali, Swetha ; Adhikari, Jayesh Vasudeva ; Jagannadh, Veerendra Kalyan ; Gorthi, Sai Siva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-81be9d8212c97a1dc02d227891a539abf72a7f91561f8fc88a74ccecd6a53d663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Automation</topic><topic>Diagnostic systems</topic><topic>Diagnostic tests</topic><topic>Digital imaging</topic><topic>Erythrocytes</topic><topic>Image acquisition</topic><topic>Image quality</topic><topic>Malaria</topic><topic>Optical components</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murali, Swetha</creatorcontrib><creatorcontrib>Adhikari, Jayesh Vasudeva</creatorcontrib><creatorcontrib>Jagannadh, Veerendra Kalyan</creatorcontrib><creatorcontrib>Gorthi, Sai Siva</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Review of scientific instruments</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murali, Swetha</au><au>Adhikari, Jayesh Vasudeva</au><au>Jagannadh, Veerendra Kalyan</au><au>Gorthi, Sai Siva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Continuous stacking computational approach based automated microscope slide scanner</atitle><jtitle>Review of scientific instruments</jtitle><addtitle>Rev Sci Instrum</addtitle><date>2018-02</date><risdate>2018</risdate><volume>89</volume><issue>2</issue><spage>023701</spage><epage>023701</epage><pages>023701-023701</pages><issn>0034-6748</issn><eissn>1089-7623</eissn><coden>RSINAK</coden><abstract>Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. 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| fulltext | fulltext |
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| ispartof | Review of scientific instruments, 2018-02, Vol.89 (2), p.023701-023701 |
| issn | 0034-6748 1089-7623 |
| language | eng |
| recordid | cdi_scitation_primary_10_1063_1_5022549 |
| source | American Institute of Physics (AIP) Journals; Alma/SFX Local Collection |
| subjects | Automation Diagnostic systems Diagnostic tests Digital imaging Erythrocytes Image acquisition Image quality Malaria Optical components |
| title | Continuous stacking computational approach based automated microscope slide scanner |
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