Continuous stacking computational approach based automated microscope slide scanner

Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. In this article, a computation augmented approach for the development of an automated microscope slide scanner is presented. The realization of a prototype device built usin...

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Veröffentlicht in:Review of scientific instruments 2018-02, Vol.89 (2), p.023701-023701
Hauptverfasser: Murali, Swetha, Adhikari, Jayesh Vasudeva, Jagannadh, Veerendra Kalyan, Gorthi, Sai Siva
Format: Artikel
Sprache:eng
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Zusammenfassung:Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. In this article, a computation augmented approach for the development of an automated microscope slide scanner is presented. The realization of a prototype device built using inexpensive off-the-shelf optical components and motors is detailed. The applicability of the developed prototype to clinical diagnostic testing is demonstrated by generating good quality digital images of malaria-infected blood smears. Further, the acquired slide images have been processed to identify and count the number of malaria-infected red blood cells and thereby perform quantitative parasitemia level estimation. The presented prototype would enable cost-effective deployment of slide-based cyto-diagnostic testing in endemic areas.
ISSN:0034-6748
1089-7623
DOI:10.1063/1.5022549