Comparing immune-tumor growth models with drug therapy using optimal control

Comparing immune-tumor growth models with drug therapy using optimal control

In this paper we compare the dynamics of three tumor growth models that include an immune system and a drug administration therapy using optimal control. The objective is to minimize a combined function of the total of tumor cells over time and a chemotherapeutic drug administration. The authors wou...

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Hauptverfasser: Martins, Marisa C., Rocha, Ana Maria A. C., Costa, M. Fernanda P., Fernandes, Edite Manuela da G. P.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Chemotherapy
Ciências Naturais
Growth models
Immune system
Matemáticas
Optimal control
Science & Technology
Tumor growth model
Tumors
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Zusammenfassung:In this paper we compare the dynamics of three tumor growth models that include an immune system and a drug administration therapy using optimal control. The objective is to minimize a combined function of the total of tumor cells over time and a chemotherapeutic drug administration. The authors would like to thank the financial support from FCT (Fundação para a Ciência e Tecnologia, Portugal) in the scope of the projects: PEst-OE/MAT/UI0013/2014 and PEst-UID/CEC/00319/2013.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.4952097