Microwave-assisted High Diastereoselective Synthesis of α -Aminophosphonates under Solvent and Catalyst Free-conditions

A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophospho-nates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik...

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Veröffentlicht in:Journal of the Mexican Chemical Society 2012-04, Vol.56 (2), p.183-187
Hauptverfasser: Tibhe, Gaurao D., Reyes-González, Miguel Ángel, Cativiela, Carlos, Ordóñez, Mario
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Sprache:eng ; por
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Zusammenfassung:A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophospho-nates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-Fields reaction), which proceeds in short time using microwave irradiation under solvent and catalyst free-conditions. This method could be useful in the large-scale synthesis of α-aminophosphonates in short reaction time.
ISSN:1870-249X