Microwave-assisted High Diastereoselective Synthesis of α -Aminophosphonates under Solvent and Catalyst Free-conditions
A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophospho-nates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik...
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Veröffentlicht in: | Journal of the Mexican Chemical Society 2012-04, Vol.56 (2), p.183-187 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng ; por |
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Zusammenfassung: | A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophospho-nates through "one-pot" three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-Fields reaction), which proceeds in short time using microwave irradiation under solvent and catalyst free-conditions. This method could be useful in the large-scale synthesis of α-aminophosphonates in short reaction time. |
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ISSN: | 1870-249X |