Association of log odds of positive lymph nodes with survival in patients with small cell lung cancer: Results from the SEER database
•The prognosis of patients with SCLC can be predicted by their LN status.•The authors aimed to assess the correlations between SCLC survival and LNR, pLNs, LODDS.•LODDS may be better than other LN assessment tools at predicting survival in SCLC. The prognosis of patients with Small Cell Lung Cancer...
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Veröffentlicht in: | Clinics (São Paulo, Brazil) Brazil), 2024-01, Vol.79, p.100369-100369, Article 100369 |
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Zusammenfassung: | •The prognosis of patients with SCLC can be predicted by their LN status.•The authors aimed to assess the correlations between SCLC survival and LNR, pLNs, LODDS.•LODDS may be better than other LN assessment tools at predicting survival in SCLC.
The prognosis of patients with Small Cell Lung Cancer (SCLC) can be predicted by their Lymph Node (LN) status. The authors aimed to assess the correlations between SCLC survival and number of LN Ratio (LNR), positive LN (pLNs), and Logarithmic Odds of positive LN (LODDS).
This cohort study retrospectively included 1,762 patients with SCLC from the SEER database 2004‒2015. The X-tile software was used to determine the cutoff values for pLNs, LNR, and LODDS. The correlations between pLNs, LNR, and LODDS with Overall Survival (OS) and Cancer-Specific Survival (CSS) were explored using Cox regression analysis. The study used the C-index to assess the predictive value of LNR, pLNs, and LODDS on survival.
Among these 1,762 patients, 121 (6.87%) were alive, 1,641 (93.13%) died, and 1,532 (86.95%) died of SCLC. In univariable COX analysis, LNR, pLNs, and LODDS all showed a correlation with CSS and OS (p < 0.05). In multivariable COX analysis, only patients with LODDS (> 0.3 vs. ≤ 0.3) were related to both worse OS (HR = 1.28, 95% CI 1.10‒1.50) and CSS (HR = 1.29, 95% CI 1.10‒1.51), but no correction was observed between LNR and pLNs and survival (p > 0.05). The C-indices for predicting OS for LODDS were 0.552 (95% CI 0.541‒0.563), for LNR 0.504 (95% CI 0.501‒0.507), and for pLNs 0.527 (95% CI 0.514‒0.540). Moreover, the association between LODDS and prognosis in SCLC patients was significant only in patients with LN stage N1 and N2, but not in stage N3.
LODDS may be better than other LN assessment tools at predicting survival in SCLC patients. |
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ISSN: | 1807-5932 1980-5322 1980-5322 |
DOI: | 10.1016/j.clinsp.2024.100369 |