Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens

Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing antibodies when inoculated in specific pathogen-free chickens demonstrating that CNP...

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Veröffentlicht in:	Brazilian journal of microbiology 2014-01, Vol.45 (1), p.231-234
Hauptverfasser:	Zanetti, Flavia Adriana, Grand, María Daniela Conte, Mitarotonda, Romina Cristina, Taboga, Oscar Alberto, Calamante, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Birnaviridae Infections - immunology Birnaviridae Infections - prevention & control Birnaviridae Infections - veterinary Canarypox virus - genetics Chickens Drug Carriers Genetic Vectors MICROBIOLOGY Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Protein expression Recombinant Proteins - genetics Recombinant Proteins - immunology Short Communication Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral infections Viral Structural Proteins - genetics Viral Structural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Viruses
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Beschreibung
Zusammenfassung:	Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing antibodies when inoculated in specific pathogen-free chickens demonstrating that CNPV platform is usefulness to develop immunogens for chickens.
ISSN:	1517-8382 1678-4405 1678-4405
DOI:	10.1590/S1517-83822014000100032