Prevalence of virulence genes among bulgarian nosocomial and cystic fibrosis isolates of Pseudomonas aeruginosa

The aim of this study was to evaluate the prevalence of some virulence genes among 202 Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients (n=42) and non-CF in-patients (n=160) and to analyze the values according to the patient groups, infection localization and antimicrobial resistan...

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Veröffentlicht in:	Brazilian journal of microbiology 2010-07, Vol.41 (3), p.588-595
Hauptverfasser:	Mitov, Ivan(Medical University of Sofia Department of Medical Microbiology), Strateva, Tanya(Medical University of Sofia Department of Medical Microbiology), Markova, Boyka(Medical University of Sofia Department of Medical Microbiology)
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Cystic fibrosis cystic fibrosis isolates Drug resistance Genes Medical Microbiology MICROBIOLOGY non-cystic fibrosis isolates Polymerase chain reaction Pseudomonas aeruginosa virulence genes
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Zusammenfassung:	The aim of this study was to evaluate the prevalence of some virulence genes among 202 Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients (n=42) and non-CF in-patients (n=160) and to analyze the values according to the patient groups, infection localization and antimicrobial resistance. The following frequencies in all studied strains were established: algD (encoding GDP-mannose 6-dehydrogenase AlgD) - 91.1%, pilB (type IV fimbrial biogenesis protein PilB) - 23.8%, nan1 (neuraminidase) - 21.3%, lasB (elastase LasB) - 100%, plcH (haemolytic phospholipase C precursor) - 91.6%, exoS (exoenzyme S) - 62.4%, and exoU (exoenzyme U) - 30.2%. The prevalence of nan1 was significantly higher (P
ISSN:	1517-8382 1678-4405 1678-4405
DOI:	10.1590/S1517-83822010000300008