Recognition and management of hereditary colorectal cancer syndromes

Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing helps diagnose affected individuals and allows identification of i...

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Veröffentlicht in:	Revista española de enfermedades digestivas 2009-02, Vol.101 (2), p.125-132
Hauptverfasser:	Herráiz, M, Muñoz-Navas, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - diagnosis Adenomatous Polyposis Coli - drug therapy Adenomatous Polyposis Coli - epidemiology Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - surgery Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Child Colectomy Colonoscopy Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Colorectal Neoplasms - prevention & control Colorectal Neoplasms - surgery Colorectal Neoplasms - therapy Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - drug therapy Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - surgery Cyclooxygenase 2 Inhibitors - therapeutic use Endometrial Neoplasms - genetics Endometrial Neoplasms - surgery Family Health Female Gastroenterology & Hepatology Genes, Dominant Genes, Neoplasm Genes, Recessive Genetic Testing Geriatrics & Gerontology Humans Infectious Diseases Male Middle Aged Neoplastic Syndromes, Hereditary - diagnosis Neoplastic Syndromes, Hereditary - drug therapy Neoplastic Syndromes, Hereditary - epidemiology Neoplastic Syndromes, Hereditary - surgery Oncology Pathology Pharmacology & Pharmacy Radiology, Nuclear Medicine & Medical Imaging Surgery Young Adult
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Zusammenfassung:	Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing helps diagnose affected individuals and allows identification of individuals at-risk. Colonoscopy and prophylactic colectomy decrease colorectal cancer incidence and overall mortality in patients with hereditary colon cancer. Extracolonic tumors are frequent in these syndromes, so specific surveillance strategies should be offered.
ISSN:	1130-0108 1130-0108
DOI:	10.4321/S1130-01082009000200006