A NON-CENTROSYMMETRIC POLYMORPH OF 5-HYDROXY-7-METHOXY-2-PHENYLCHROMAN-4-ONE

A NON-CENTROSYMMETRIC POLYMORPH OF 5-HYDROXY-7-METHOXY-2-PHENYLCHROMAN-4-ONE

The bioactive compound 5-hydroxy-7-methoxy-2-phenylchroman-4-one (pinostrobin, I), was isolated from aerial parts of Nolana ramossisima I.M. Johnst., a Chilean endemic species, using a combination of medium pressure column chromatography and high speed countercurrent liquid-liquid chromatography (HS...

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Veröffentlicht in:Journal of the Chilean Chemical Society 2015-03, Vol.60 (1), p.2864-2866
Hauptverfasser: BRITO, IVÁN, SIMIRGIOTIS, MARIO J, BRITO, ANGHEL, RODRÍGUEZ WERNER, MIRIAM, BÓRQUEZ, JORGE, WINTERHALTER, PETER, CÁRDENAS, ALEJANDRO
Format: Artikel
Sprache:eng
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CHEMISTRY, MULTIDISCIPLINARY
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Zusammenfassung:The bioactive compound 5-hydroxy-7-methoxy-2-phenylchroman-4-one (pinostrobin, I), was isolated from aerial parts of Nolana ramossisima I.M. Johnst., a Chilean endemic species, using a combination of medium pressure column chromatography and high speed countercurrent liquid-liquid chromatography (HSCCC). The compound crystallized as a non-centrosymmetric polymorph in the orthorhombic chiral space group P2(1)2(1)2(1). Its structure had been previously reported by Shoja (Acta Cryst. C45, 828, 1989) and Yamovoi et al. (Khim. Prir. Soedin (5), 361, 2001) in the centrosymmetric space groups Pbca and P21/c, respectively.
ISSN:0717-9707
0717-9707
DOI:10.4067/S0717-97072015000100020