Laboratory testing in the evaluation of a monoclonal protein: A practical framework for interpretation
Monoclonal proteins are immunoglobulins secreted by identical but abnormal plasma cells that are clones of a parent cell. While routine screening in the absence of signs or symptoms of disease is not recommended, testing is indicated in the diagnostic work-up for multiple myeloma and other plasma ce...
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Veröffentlicht in: | SAMJ: South African Medical Journal 2019-10, Vol.109 (10), p.719-722 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | por |
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Zusammenfassung: | Monoclonal proteins are immunoglobulins secreted by identical but abnormal plasma cells that are clones of a parent cell. While routine screening in the absence of signs or symptoms of disease is not recommended, testing is indicated in the diagnostic work-up for multiple myeloma and other plasma cell disorders. When indicated, a serum protein electrophoresis with immunofixation and serum free light-chain assay should be performed to determine the type and quantity of monoclonal protein. Using a case-based approach, we highlight common misconceptions with monoclonal protein investigations, and suggest a practical framework for diagnostic interpretation. |
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ISSN: | 2078-5135 |
DOI: | 10.7196/samj.2019.v109il0.14314 |