Photodegradation of Fluoxetine Applying Different Photolytic Reactors: Evaluation of the Process Efficiency and Mechanism

Photolytic degradation of fluoxetine (FLX), a medicine commonly known as Prozac®, was evaluated by using different photochemical processes. The ultraviolet/microwave (UV/MW) process showed higher efficiency in all the aspects evaluated in this study. The energy consumption was equivalent to 1.94 × 1...

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Veröffentlicht in:Journal of the Brazilian Chemical Society 2019-05, Vol.30 (5), p.1010-1024
Hauptverfasser: Moreira, Ailton, Borges, Aline, de Sousa, Bianca, de Mendonça, Vagner, Freschi, Carolina, Freschi, Gian
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Sprache:eng
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Zusammenfassung:Photolytic degradation of fluoxetine (FLX), a medicine commonly known as Prozac®, was evaluated by using different photochemical processes. The ultraviolet/microwave (UV/MW) process showed higher efficiency in all the aspects evaluated in this study. The energy consumption was equivalent to 1.94 × 10-4 kW h mg-1 L (UV/MW), while in the UV process the value was 1.20 × 10-2 kW h mg-1 L. The degradation kinetics were applied to the FLX, with rate constant (k) = 0.15 ± 0.01 min-1 and linear correlation coefficient (R2) = 0.980 for UV, and k = 6.15 ± 0.08 min-1 and R2 = 0.998 for UV/MW. The FLX degradation of 99.16% (UV/MW 5 min) and 98.90% (UV 120 min) were observed, evidencing higher efficiency for the first process. The monitoring of transformation products (TPs) through chromatographic analysis enabled the identification of 9 TPs, proving that for the UV/MW process, the hydroxylated structures are verified in high quantity.
ISSN:0103-5053
1678-4790
1678-4790
DOI:10.21577/0103-5053.20180250