Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε‑caprolactone)-poly(ethylene oxide) and F127

Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε‑caprolactone)-poly(ethylene oxide) and F127

Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic dru...

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Veröffentlicht in:Journal of the Brazilian Chemical Society 2017-07, Vol.28 (7), p.1341-1346
Hauptverfasser: Dutra, Lillian, Cavalcante, Igor, de Brito, Débora, Vieira, Ícaro, Trevisan, Maria, Ribeiro, Maria, Yeates, Stephen, Ricardo, Nágila
Format: Artikel
Sprache:eng
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CHEMISTRY, MULTIDISCIPLINARY
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Zusammenfassung:Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.
ISSN:0103-5053
1678-4790
DOI:10.21577/0103-5053.20160302