Grandisin caused morphological changes larval and toxicity on Aedes aegypti

Grandisin caused morphological changes larval and toxicity on Aedes aegypti

Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperace...

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Veröffentlicht in:Revista brasileira de farmacognosia 2012-06, Vol.22 (3), p.517-521
Hauptverfasser: Leite, Ana Carolina C. F., Kato, Massuo J., Soares, Renata O. A., Guimarães, Anthony E., Santos-Mallet, Jacenir R., Cabral, Marise M. O.
Format: Artikel
Sprache:eng
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PHARMACOLOGY & PHARMACY
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Zusammenfassung:Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2012005000016