Immunodiagnosis of chronic Chagas' disease using the Tc 46 and Tc 58 antigens

The polypeptides of 46 and 58 kDa were recognized in different T. cruzi strains (Y, WSL and Colombiana) by serum of all chagasic patients studied. These polypeptides were isolated from T. cruzi Y strain and used in ELISA. The sensitivity and specificity were 97.6% [CI 95%: 86-100%] and 100% [CI 95%:...

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Veröffentlicht in:	Revista da Sociedade Brasileira de Medicina Tropical 2000-07, Vol.33 (4), p.367-370
Hauptverfasser:	Pereira, V R, Nakazawa, M, Furtado, V C, Abath, F G, Gomes, Y M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - analysis Chagas Disease - diagnosis Chronic Disease Enzyme-Linked Immunosorbent Assay - methods Humans Molecular Weight Sensitivity and Specificity TROPICAL MEDICINE Trypanosoma cruzi Vector-borne diseases
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Beschreibung
Zusammenfassung:	The polypeptides of 46 and 58 kDa were recognized in different T. cruzi strains (Y, WSL and Colombiana) by serum of all chagasic patients studied. These polypeptides were isolated from T. cruzi Y strain and used in ELISA. The sensitivity and specificity were 97.6% [CI 95%: 86-100%] and 100% [CI 95%: 89.3-100%], respectively when Tc 46 was used. When Tc 58 was used the sensitivity and specificity were 100% [CI 95%: 89.6-100%] and 90.2% [CI 95%: 75.9-96.8%], respectively.
ISSN:	0037-8682 1678-9849 0037-8682 1678-9849
DOI:	10.1590/S0037-86822000000400006