LEISHMANICIDAL ACTIVITY OF Echinaster (Othilia) echinophorus CRUDE EXTRACT

In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate t...

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Veröffentlicht in:	Revista do Instituto de Medicina Tropical de São Paulo 2010-03, Vol.52 (2), p.89-93
Hauptverfasser:	GARCIA PARRA, Marley, MONZOTE FIDALGO, Lianet, MENDIOLA MARTINEZ, Judith, MONTALVO ALVAREZ, Ana Margarita, VALDES IGLESIAS, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Biological and medical sciences Echinodermata - chemistry General aspects Leishmania - drug effects Leishmaniasis - drug therapy Lethal Dose 50 Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments TROPICAL MEDICINE
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Zusammenfassung:	In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.
ISSN:	0036-4665 1678-9946 1678-9946 0036-4665
DOI:	10.1590/S0036-46652010000200005