PORTAL CD4+ AND CD8+ T LYMPHOCYTE CORRELATE TO INTENSITY OF INTERFACE HEPATITIS IN CHRONIC HEPATITIS C

The pathogenesis of chronic hepatitis C is still a matter of debate. CD4+ and CD8+ T lymphocytes (TL) are typically observed within the portal and periportal spaces of affected livers, but their functional role in hepatitis C progression has not been fully elucidated. CD4+ and CD8+ TL were quantifie...

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Veröffentlicht in:Revista do Instituto de Medicina Tropical de São Paulo 2007-11, Vol.49 (6), p.371-378
Hauptverfasser: RODRIGUEZ VISO, Ana Teresa, DE CASTRO BARBOSA, Thais, YAMAMOTO, Lidia, PAGLIARI, Carla, FERNANDES, Elaine Raniero, BRASIL, Roosecelis Araujo, DE ANDRADE JUNIOR, Heitor Franco, DUARTE, Maria Irma Seixas, BARONE, Antonio Alci
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Sprache:eng
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Zusammenfassung:The pathogenesis of chronic hepatitis C is still a matter of debate. CD4+ and CD8+ T lymphocytes (TL) are typically observed within the portal and periportal spaces of affected livers, but their functional role in hepatitis C progression has not been fully elucidated. CD4+ and CD8+ TL were quantified by immunohistochemistry in portal and periportal spaces of 39 liver biopsies from patients with chronic hepatitis C. They were associated to demographic data, histological parameters, laboratory findings of patients and hepatitis C genotypes. There was high numbers of CD4+ and CD8+ TL from which the density of CD4+ T was higher than CD8+ TL in portal and periportal spaces. CD4+ and CD8+ TL were directly correlated to intensity of interface hepatitis. CD8+ TL correlated to serum enzyme levels. The high numbers of CD4+ and CD8+ TL in portal and periportal spaces and their correlation to interface hepatitis suggest that hepatitis C evolution depends on the action of intrahepatic T lymphocytes, lending support to the notion of an immune-mediated mechanism in the pathogenesis of chronic hepatitis C.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46652007000600007