Glucose as Adjunct to 3,3-Dimethyl-1-Phenvltriazene in its Action upon Sarcoma 180

Summary The effects of intraperitoneal injections of 3,3-dimethyl-1-phenyltriazene dissolved in peanut oil and of subcutaneous injections of glucose, separately and in combination, upon growth rate of Sarcoma 180 in mice were measured. The triazene markedly depressed tumor growth. This effect was only slightly altered by injections of glucose. Glucose itself had a slight effect upon tumor growth. The triazene disappeared rapidly from the abdominal cavity. By acidification and coupling with N-(1-naphthyl)-ethylene-diamine, it could be demonstrated in tissue. Triazene injections were without effect on blood sugar.