Adrenal Corticoid Activities of 6-Methyl-Δ1-Hydrocortisone

Summary Comparisons are presented on relative potencies of Δ1-F and a new analogue, 6-methyl-Δ1-F, on 3 different assays for corticoid activity: anti-inflammatory (granuloma pouch technic), liver glycogen deposition, and sodium retention. 6-Methyl-Δ1-F is 2 times as potent as Δ1-F on the anti-inflammatory test and about 3 times Δ1-F on the glycogen deposition assay. 6-Methyl-Δ1-F, like Δ1-F, does not induce sodium and water retention on the assay for electrolyte activity, but in contrast to Δ1-F, this steroid acts as a diuretic and natriuretic agent.