Glucocorticoid and Mineralocorticoid Activities of Δ1-Fluorohydrocortisonei

Summary (1) Comparisons have been made of relative potencies of hydrocortisone, fluorohydrocortisone, Δ1-hydrocortisone, and Δ1-fluorohydrocortisone in causing deposition of liver glycogen and reduction of sodium excretion in the adrenalectomized rat. (2) In glycogen deposition potency, the compounds have activity of the following magnitude: Δ1-fluorohydrocortisone acetate-50; fluorohy-drocortisone acetate-12.6; Δ1-hydrocorti-sone-2.9; hydrocortisone-1. (3) In sodium-retaining potency, the compounds have activity of the following magnitude: Δ1-fluorohydrocortisone acetate-4.6; fluorohydro-cortisone acetate-5.0; Δ1-hydrocortisone acetate-very slight; hydrocortisone acetate -very slight; DOCA-1.