Growth-Survival and Sodium Retaining Activity of 9 a-Halo Derivatives of Hydrocortisone

Summary 1. Growth and survival studies on adrenalectomized immature rats following single injections of aqueous suspensions of steroids indicate that Chloro F acetate is 10 to 20 times and Bromo F acetate 2 to 5 times as active as DCA. E acetate, F acetate, and Fluoro F acetate are less effective than DCA. 2. Sodium retention tests with Na22 indicate that Chloro F acetate is 10.8 times as potent as DCA, and that Fluoro F acetate is somewhat more effective and Bromo F acetate considerably less effective than DCA. The dose-response curves suggest that the steroids cause sodium retention by more than one mechanism. 3. The data indicate that, with the steroids studied, there is not always a direct correlation between sodium-retaining activity and growth-survival activity.