Effect of Vitamin B12 on Experimental Hepatic Injury.

Summary Vit. B12 (1 γ daily, by mouth) had no effect on the development of massive hepatic necrosis in rats fed experimental rations with yeast as sole source of protein. Vit. B12 (0.5 γ daily by mouth) has shown significant lipotropic activity in rats fed a low protein-low fat ration. Under the exp...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1950-03, Vol.73 (3), p.372-375
Hauptverfasser: Gyorgy, Paul, Rose, Catharine S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Summary Vit. B12 (1 γ daily, by mouth) had no effect on the development of massive hepatic necrosis in rats fed experimental rations with yeast as sole source of protein. Vit. B12 (0.5 γ daily by mouth) has shown significant lipotropic activity in rats fed a low protein-low fat ration. Under the experimental conditions chosen methionine was more effective than vitamin B12 in preventing fat deposition in the liver. A low protein-high fat diet seemed to interfere with the lipotropic effect of B12.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-73-17686