Some Effects of Protein Depletion and 2-Acetylaminofluorene on Activity of Rat Plasma Pseudocholinesterase

Summary Evidence is presented for the identity Df the plasma pseudocholinesterase of dog and rat and that the latter enzyme is stable when stored at low temperatures. Protein starvation is accompanied by a decrease in rat plasma pseudocholinesterase activity. The activity of this enzyme has been shown to increase markedly in rats fed 2-acetylaminofluorene before any gross evidence od hepatoma can be detected. As the hepatoma develops and liver protein concentration declines, the pseudocholinesterase activity of the plasma decreases from this high level.