Myocardial Extraction of Labeled Long-Chain Fatty Acid Analogs 1

Summary The single circulation myocardial extraction of terminally iodinated hexadecenoic acid (77 ± 11.0%) is approximately two times the extraction of 18 carbon fatty acids (33 ± 5.2%) prepared by iodination of double bonds. The results compare favorably with natural 18 carbon stearic (70 ± 7.5%) and oleic (61 ± 7.8%) acids labeled with carbon-11 in the carboxyl group. It is concluded that terminally radioiodinated long chain fatty acids can be used as substitutes for in vivo investigations of fatty acid distribution and in particular may be useful as a regional myocardial blood flow indicator. The authors are indebted to Mrs. Alice Lee, Mr. Carl Selin, and Mr. Joe Takahashi for technical assistance.