Effects of Sera and Sera Fractions from Spontaneously Hypertensive Rats on Renal Organic Anion and Cation Transport 1 2

Summary Sera taken from spontaneously hypertensive Wistar rats compared to sera from normotensive Wistar rats depressed both PAH and TEA systems in kidney slices from normotensive Sprague-Dawley rats. This depression was found to reside in a specific fraction of sera separated on Sephadex columns, the same fraction which in azotemic sera suppresses both PAH transport and sodium transport in vitro. The observation that factors in sera affect organic anion and cation transport early in the development of hypertension may have implications in the pathogenesis of hypertension.