The Effect of Hemorrhagic Shock on the Phospholipid Composition of Blood Plasma of Anesthetized Dogs 1

Summary The phospholipid composition of arterial, sagittal sinus and hepatic venous blood plasma was investigated in dogs under pentobarbital anesthesia both before and shortly after a severe hemorrhage. The total lipid P concentration in the artery decreased following hemorrhage, but the phosphatidyl-glycerol concentration increased. Only small and variable differences were observed across the splanchnic region either before or after the bleeding. A significant release of total lipid P, phosphatidyl ethanolamine, choline plasmalogen and phosphatidylglycerol was noted across the brain under control conditions. The individual phospholipids were continued to be released even following hemorrhage. The physiological significance of these changes will have to await further study.